Assay Detail
Functional
CHEMBL697025
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration to achieve half-maximal inhibition of acid-induced swelling in human platelets using platelet swelling assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Bicyclic acylguanidine Na+/H+ antiporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.40 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | 7.50 |
| CHEMBL124044 | — | — | 1 | 7.11 |
| CHEMBL124547 | — | — | 1 | 7.11 |
| CHEMBL333059 | — | — | 1 | 7.11 |
| CHEMBL331794 | — | — | 1 | 6.99 |
| CHEMBL122142 | — | — | 1 | 6.94 |
| CHEMBL332433 | — | — | 1 | 6.94 |
| CHEMBL436559 | CARIPORIDE | 2.0 | 1 | 6.93 |
| CHEMBL126060 | — | — | 1 | 6.86 |
| CHEMBL125283 | — | — | 1 | 6.80 |
| CHEMBL273539 | — | — | 1 | 6.74 |
| CHEMBL124274 | — | — | 1 | 6.71 |
| CHEMBL445376 | — | — | 1 | 6.68 |
| CHEMBL331630 | — | — | 1 | 6.59 |
| CHEMBL439605 | — | — | 1 | 6.56 |
| CHEMBL126367 | — | — | 1 | 6.51 |
| CHEMBL331457 | — | — | 1 | 6.49 |
| CHEMBL122853 | — | — | 1 | 6.45 |
| CHEMBL124762 | — | — | 1 | 6.31 |
| CHEMBL123160 | — | — | 1 | 6.28 |
| CHEMBL341296 | — | — | 1 | 6.27 |
| CHEMBL124884 | — | — | 1 | 6.23 |
| CHEMBL125952 | — | — | 1 | 6.18 |
| CHEMBL125951 | — | — | 1 | 6.16 |
| CHEMBL123859 | — | — | 1 | 6.07 |
| CHEMBL333804 | — | — | 1 | 5.98 |
| CHEMBL421240 | — | — | 1 | 5.96 |
| CHEMBL121787 | — | — | 1 | 5.93 |
| CHEMBL122238 | — | — | 1 | 5.68 |
| CHEMBL330935 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64360 | ENIPORIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL124044 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL333059 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL124547 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL331794 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL122142 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL332433 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL126060 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL125283 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL273539 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL124274 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL445376 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL331630 | — | IC50 | = | 258.0 | nM | 6.59 |
| CHEMBL439605 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL126367 | — | IC50 | = | 306.0 | nM | 6.51 |
| CHEMBL331457 | — | IC50 | = | 321.0 | nM | 6.49 |
| CHEMBL122853 | — | IC50 | = | 354.0 | nM | 6.45 |
| CHEMBL124762 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL123160 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL341296 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL124884 | — | IC50 | = | 587.0 | nM | 6.23 |
| CHEMBL125952 | — | IC50 | = | 655.0 | nM | 6.18 |
| CHEMBL125951 | — | IC50 | = | 692.0 | nM | 6.16 |
| CHEMBL123859 | — | IC50 | = | 843.0 | nM | 6.07 |
| CHEMBL333804 | — | IC50 | = | 1054.0 | nM | 5.98 |
| CHEMBL421240 | — | IC50 | = | 1099.0 | nM | 5.96 |
| CHEMBL121787 | — | IC50 | = | 1181.0 | nM | 5.93 |
| CHEMBL122238 | — | IC50 | = | 2076.0 | nM | 5.68 |
| CHEMBL330935 | — | IC50 | = | 2322.0 | nM | 5.63 |
| CHEMBL121732 | — | IC50 | = | 3666.0 | nM | 5.44 |
| CHEMBL333480 | — | IC50 | = | 5034.0 | nM | 5.30 |
| CHEMBL340249 | — | IC50 | = | 14292.0 | nM | 4.84 |
| CHEMBL124987 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL124826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL333112 | — | IC50 | > | 100000.0 | nM | - |