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Assay Detail

CHEMBL697026

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Functional
in vitro inhibition of human gel-filtered platelets
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.
Hutchinson JH, Cook JJ, Brashear KM, Breslin MJ, Glass JD, Gould RJ, Halczenko W, Holahan MA, Lynch RJ, Sitko GR, Stranieri MT, Hartman GD.
J Med Chem (1996) 39 : 4583 -4591
PubMed 8917647 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 7.49 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL143084 1 8.22
CHEMBL57886 1 7.92
CHEMBL357888 1 7.82
CHEMBL343235 1 7.80
CHEMBL434444 1 7.75
CHEMBL341938 1 7.72
CHEMBL140529 1 7.52
CHEMBL141196 1 7.46
CHEMBL140732 1 6.50
CHEMBL141185 1 6.20

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL143084 IC50 = 6.0 nM 8.22
CHEMBL57886 IC50 = 12.0 nM 7.92
CHEMBL357888 IC50 = 15.0 nM 7.82
CHEMBL343235 IC50 = 16.0 nM 7.80
CHEMBL434444 IC50 = 18.0 nM 7.75
CHEMBL341938 IC50 = 19.0 nM 7.72
CHEMBL140529 IC50 = 30.0 nM 7.52
CHEMBL141196 IC50 = 35.0 nM 7.46
CHEMBL140732 IC50 = 320.0 nM 6.50
CHEMBL141185 IC50 = 630.0 nM 6.20