Assay Detail
Functional
CHEMBL697027
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in vitro inhibition of human gel-filtered platelets using ADP agonist
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.03 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58328 | — | — | 1 | 7.89 |
| CHEMBL141024 | — | — | 1 | 7.57 |
| CHEMBL141394 | — | — | 1 | 7.09 |
| CHEMBL140217 | — | — | 1 | 6.85 |
| CHEMBL140593 | — | — | 1 | 6.80 |
| CHEMBL344615 | — | — | 1 | 6.50 |
| CHEMBL141189 | — | — | 1 | 6.48 |
| CHEMBL344054 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58328 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL141024 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL141394 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL140217 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL140593 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL344615 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL141189 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL344054 | — | IC50 | > | 300000.0 | nM | - |