Assay Detail
Binding
CHEMBL697044
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Kinetic inhibition constant of compound with Trypanosoma cruzi Hypoxanthine Phosphoribosyltransferase (HPRT)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Hypoxanthine-guanine phosphoribosyltransferase (CHEMBL2360) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Analysis of 6-(2,2-Dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.57 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88057 | — | — | 1 | 6.30 |
| CHEMBL313154 | — | — | 1 | 6.22 |
| CHEMBL87526 | — | — | 1 | 5.70 |
| CHEMBL83185 | — | — | 1 | 5.66 |
| CHEMBL83242 | — | — | 1 | 5.55 |
| CHEMBL82858 | — | — | 1 | 5.17 |
| CHEMBL85685 | CHRYSENE | — | 1 | 5.05 |
| CHEMBL83231 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88057 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL313154 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL87526 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL83185 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL83242 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL82858 | — | Ki | = | 6700.0 | nM | 5.17 |
| CHEMBL85685 | CHRYSENE | Ki | = | 8980.0 | nM | 5.05 |
| CHEMBL83231 | — | Ki | = | 11800.0 | nM | 4.93 |