Assay Detail
Binding
CHEMBL697085
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Binding affinity at rat cortical Histamine 3 receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.84 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25688 | — | — | 1 | 7.38 |
| CHEMBL104669 | — | — | 1 | 7.29 |
| CHEMBL105267 | — | — | 1 | 7.20 |
| CHEMBL318320 | — | — | 1 | 7.01 |
| CHEMBL318801 | — | — | 1 | 6.90 |
| CHEMBL102452 | — | — | 1 | 6.89 |
| CHEMBL105385 | — | — | 1 | 6.72 |
| CHEMBL105952 | — | — | 1 | 6.21 |
| CHEMBL105268 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25688 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL104669 | — | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL105267 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL318320 | — | Ki | = | 97.72 | nM | 7.01 |
| CHEMBL318801 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL102452 | — | Ki | = | 128.82 | nM | 6.89 |
| CHEMBL105385 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL105952 | — | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL105268 | — | Ki | = | 1122.02 | nM | 5.95 |