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Assay Detail

CHEMBL697148

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Compound was tested for the antiviral activity against Human Rhinovirus -14(HRV-14) in HeLa cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Intermediate

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.
Webber SE, Tikhe J, Worland ST, Fuhrman SA, Hendrickson TF, Matthews DA, Love RA, Patick AK, Meador JW, Ferre RA, Brown EL, DeLisle DM, Ford CE, Binford SL.
J Med Chem (1996) 39 : 5072 -5082
PubMed 8978838 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 12 4.53 5.20

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL150011 1 5.20
CHEMBL348660 1 4.85
CHEMBL64582 1 4.25
CHEMBL148483 1 4.18
CHEMBL64413 1 4.15
CHEMBL146403 1 -
CHEMBL149950 1 -
CHEMBL149822 1 -
CHEMBL149227 1 -
CHEMBL149556 1 -
CHEMBL145833 1 -
CHEMBL358279 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL150011 EC50 = 6300.0 nM 5.20
CHEMBL348660 EC50 = 14100.0 nM 4.85
CHEMBL64582 EC50 = 56000.0 nM 4.25
CHEMBL148483 EC50 = 66000.0 nM 4.18
CHEMBL64413 EC50 = 71000.0 nM 4.15
CHEMBL146403 EC50 > 20000.0 nM -
CHEMBL149950 EC50 > 5600.0 nM -
CHEMBL149822 EC50 > 20000.0 nM -
CHEMBL149227 EC50 > 7100.0 nM -
CHEMBL149556 EC50 > 100000.0 nM -
CHEMBL145833 EC50 > 100000.0 nM -
CHEMBL358279 EC50 > 10000.0 nM -