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Assay Detail

CHEMBL697155

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of human platelet aggregation induced by thromboxane mimetic U-46,619 (at a concentration of 0.3 uM)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Thrombin receptor (PAR-1) antagonists. Solid-phase synthesis of indole-based peptide mimetics by anchoring to a secondary amide.
Zhang HC, McComsey DF, White KB, Addo MF, Andrade-Gordon P, Derian CK, Oksenberg D, Maryanoff BE.
Bioorg Med Chem Lett (2001) 11 : 2105 -2109
PubMed 11514149 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.49 4.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL63402 1 4.90
CHEMBL293867 1 4.67
CHEMBL303157 1 4.58
CHEMBL303187 1 4.48
CHEMBL304829 1 4.44
CHEMBL68458 1 4.40
CHEMBL63966 1 4.38
CHEMBL62775 1 4.36
CHEMBL302603 1 4.36
CHEMBL431369 1 4.35

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL63402 IC50 = 12500.0 nM 4.90
CHEMBL293867 IC50 = 21400.0 nM 4.67
CHEMBL303157 IC50 = 26200.0 nM 4.58
CHEMBL303187 IC50 = 33000.0 nM 4.48
CHEMBL304829 IC50 = 36300.0 nM 4.44
CHEMBL68458 IC50 = 39500.0 nM 4.40
CHEMBL63966 IC50 = 41900.0 nM 4.38
CHEMBL62775 IC50 = 44200.0 nM 4.36
CHEMBL302603 IC50 = 43500.0 nM 4.36
CHEMBL431369 IC50 = 44400.0 nM 4.35