Assay Detail
Binding
CHEMBL697170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]AMPA binding to Ionotropic glutamate receptor AMPA.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.89 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9790 | — | — | 1 | 6.43 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 5.40 |
| CHEMBL48037 | — | — | 1 | 4.51 |
| CHEMBL296705 | — | — | 1 | 4.48 |
| CHEMBL265301 | — | — | 1 | 4.46 |
| CHEMBL291274 | — | — | 1 | 4.05 |
| CHEMBL295310 | — | — | 1 | - |
| CHEMBL298469 | — | — | 1 | - |
| CHEMBL48054 | — | — | 1 | - |
| CHEMBL47945 | — | — | 1 | - |
| CHEMBL295692 | — | — | 1 | - |
| CHEMBL297648 | — | — | 1 | - |
| CHEMBL44777 | — | — | 1 | - |
| CHEMBL48038 | — | — | 1 | - |
| CHEMBL45698 | — | — | 1 | - |
| CHEMBL298490 | — | — | 1 | - |
| CHEMBL42885 | — | — | 1 | - |
| CHEMBL47277 | — | — | 1 | - |
| CHEMBL44059 | — | — | 1 | - |
| CHEMBL297999 | — | — | 1 | - |
| CHEMBL295778 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9790 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL275040 | KAINIC ACID | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL48037 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL296705 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL265301 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL291274 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL295310 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298469 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL48054 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL47945 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295692 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297648 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44777 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL48038 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL45698 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298490 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42885 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL47277 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL44059 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL297999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295778 | — | IC50 | > | 100000.0 | nM | - |