Compound Detail
CHEMBL48037
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL48037 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYIHRWGRFPHJBD-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
280.2
MW (Da)
-0.55
ALogP
6
HBA
4
HBD
156.1
PSA (Ų)
0.50
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.16 | 4.63 | 6900.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 6900.0 | nM | 5.16 | In vitro inhibition of [3H]CNQX binding to Ionotropic glutamate receptor AMPA. | 8648608 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 31000.0 | nM | 4.51 | In vitro inhibition of [3H]AMPA binding to Ionotropic glutamate receptor AMPA. | 8648608 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 60000.0 | nM | 4.22 | Inhibition of AMPA induced electrophysiological responses in rat cortical slices... | 8648608 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8648608 | 10.1021/jm950826p | Glutamate receptor ionotropic, AMPA | 3 |
| 8648608 | 10.1021/jm950826p | Glutamate NMDA receptor | 1 |
| 8648608 | 10.1021/jm950826p | Glutamate receptor ionotropic, kainate | 1 |
Data from ChEMBL 36 via Core Engine