Assay Detail
Functional
CHEMBL697177
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit contraction of human umbilical vein (HUV) induced by [des-Arg10]-Kallidin was determined.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Umbilical vein |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of bradykinin B(1)/B(2) and selective B(1) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 7 | 7.62 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142391 | — | — | 1 | 8.50 |
| CHEMBL3085458 | — | — | 1 | 8.00 |
| CHEMBL2369827 | — | — | 1 | 7.90 |
| CHEMBL2369828 | — | — | 1 | 7.50 |
| CHEMBL412824 | — | — | 1 | 7.40 |
| CHEMBL80472 | — | — | 1 | 6.40 |
| CHEMBL3142396 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142391 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL3085458 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL2369827 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL2369828 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL412824 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL80472 | — | Kd | = | 398.11 | nM | 6.40 |
| CHEMBL3142396 | — | Kd | > | 10000.0 | nM | - |