Assay Detail
Binding
CHEMBL697286
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Inhibitory activity against histone deacetylases (HDAC1) prepared from mouse melanoma B16/BL6 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | B16/BL6 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.87 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790587 | — | — | 1 | 9.40 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.72 |
| CHEMBL1790586 | — | — | 1 | 7.58 |
| CHEMBL1790596 | — | — | 1 | 7.48 |
| CHEMBL1790599 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790587 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1790586 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL1790596 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1790599 | — | IC50 | = | 67.0 | nM | 7.17 |