Assay Detail
Binding
CHEMBL697288
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In vitro for anti-HDAC1 (Histone deacetylase 1) activity in mouse A20 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | A20 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.34 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.70 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.95 |
| CHEMBL51060 | — | — | 1 | 5.38 |
| CHEMBL51356 | — | — | 1 | 5.35 |
| CHEMBL13168 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL51060 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL51356 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL13168 | — | IC50 | = | 4900.0 | nM | 5.31 |