Assay Detail
Binding
CHEMBL697295
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Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) receptors stably expressed in CHO cells
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.19 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357807 | — | — | 1 | 8.70 |
| CHEMBL83894 | FANANSERIN | 2.0 | 1 | 6.75 |
| CHEMBL148348 | — | — | 1 | 6.31 |
| CHEMBL148418 | — | — | 1 | 6.28 |
| CHEMBL146233 | — | — | 1 | 6.24 |
| CHEMBL359270 | — | — | 1 | 6.19 |
| CHEMBL146485 | — | — | 1 | 6.19 |
| CHEMBL146998 | — | — | 1 | 6.17 |
| CHEMBL147164 | — | — | 1 | 6.15 |
| CHEMBL147431 | — | — | 1 | 6.12 |
| CHEMBL149423 | — | — | 1 | 6.08 |
| CHEMBL150210 | — | — | 1 | 6.00 |
| CHEMBL148058 | — | — | 1 | 6.00 |
| CHEMBL343411 | — | — | 1 | 5.96 |
| CHEMBL149510 | — | — | 1 | 5.96 |
| CHEMBL122761 | — | — | 1 | 5.96 |
| CHEMBL149429 | — | — | 1 | 5.96 |
| CHEMBL74355 | VOLINANSERIN | 3.0 | 1 | 5.89 |
| CHEMBL145939 | — | — | 1 | 5.85 |
| CHEMBL146595 | — | — | 1 | 5.82 |
| CHEMBL146144 | — | — | 1 | 5.77 |
| CHEMBL423206 | — | — | 1 | 5.75 |
| CHEMBL147048 | — | — | 1 | - |
| CHEMBL148565 | — | — | 1 | - |
| CHEMBL358839 | — | — | 1 | - |
| CHEMBL146620 | — | — | 1 | - |
| CHEMBL504699 | — | — | 1 | - |
| CHEMBL150220 | — | — | 1 | - |
| CHEMBL146448 | — | — | 1 | - |
| CHEMBL148280 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357807 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL83894 | FANANSERIN | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL148348 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL148418 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL146233 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL359270 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL146485 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL146998 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL147164 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL147431 | — | Ki | = | 750.0 | nM | 6.12 |
| CHEMBL149423 | — | Ki | = | 840.0 | nM | 6.08 |
| CHEMBL150210 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL148058 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL343411 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL149510 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL122761 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL149429 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL74355 | VOLINANSERIN | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL145939 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL146595 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL146144 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL423206 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL147048 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL148565 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL358839 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL146620 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL504699 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL150220 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL146448 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL148280 | — | Ki | > | 1500.0 | nM | - |
| CHEMBL358075 | — | Ki | > | 1500.0 | nM | - |