Compound Detail
CHEMBL147164
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL147164 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PCWXMSHXEKJUAY-UHFFFAOYSA-N |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
361.4
MW (Da)
4.51
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 5 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 8.4 | 8.4 | 4.0 | 1 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | Ki | 8.3 | 8.3 | 5.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | Ki | 6.37 | 6.37 | 430.0 | 1 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 6.36 | 6.36 | 440.0 | 1 |
| D(2) dopamine receptor CHEMBL217 | Ki | 6.15 | 6.15 | 710.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Ki | = | 4.0 | nM | 8.4 | Binding affinity for displacement of [3H]ketanserin to rat 5-hydroxytryptamine 2... | 11784153 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 5.0 | nM | 8.3 | Binding affinity for displacement of [3H]ketanserin to human 5-hydroxytryptamine... | 11784153 |
| Adrenergic receptor alpha-1 | Ki | = | 430.0 | nM | 6.37 | Binding affinity for displacement of [3H]prazosin to rat Alpha-1 adrenergic rece... | 11784153 |
| 5-hydroxytryptamine receptor 2C | Ki | = | 440.0 | nM | 6.36 | Binding affinity for displacement of [3H]mesulergine to human 5-hydroxytryptamin... | 11784153 |
| D(2) dopamine receptor | Ki | = | 710.0 | nM | 6.15 | Binding affinity for displacement of [3H]spiperone to human dopamine D2 (hD2) re... | 11784153 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11784153 | 10.1021/jm011030v | 5-hydroxytryptamine receptor 2A | 2 |
| 11784153 | 10.1021/jm011030v | 5-hydroxytryptamine receptor 2C | 1 |
| 11784153 | 10.1021/jm011030v | D(2) dopamine receptor | 1 |
| 11784153 | 10.1021/jm011030v | Adrenergic receptor alpha-1 | 1 |
Data from ChEMBL 36 via Core Engine