5-hydroxytryptamine receptor 2A · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P14842. Use UniProt P14842 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P14842 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A, mapped to UniProt P14842. Sequence length is 471 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 2A as ChEMBL target CHEMBL322, mapped to UniProt P14842. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-hydroxytryptamine receptor 2A is the right protein anchor across sources, using UniProt P14842 as the stable mapping.
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| Preferred Name | 5-hydroxytryptamine receptor 2A |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P14842 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 2A |
| UniProt Accession | P14842 |
| Component Type | Protein |
| Sequence Length | 471 aa |
5-hydroxytryptamine receptor 2A
Review this target as 5-hydroxytryptamine receptor 2A, mapped to UniProt P14842. Sequence length is 471 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3763812 | 10.9 | Ki | 0.0126 | Preclinical |
| CHEMBL1927096 | 10.79 | Ki | 0.0161 | Preclinical |
| CHEMBL1927096 | 10.66 | IC50 | 0.0217 | Preclinical |
| CHEMBL4205290 | 10.65 | Ki | 0.0224 | Preclinical |
| CHEMBL3763474 | 10.41 | Ki | 0.039 | Preclinical |
| CHEMBL3617113 | 10.37 | Ki | 0.043 | Preclinical |
| CHEMBL3765231 | 10.34 | Ki | 0.046 | Preclinical |
| CHEMBL83894 | 10.22 | Ki | 0.06 | Clinical |
| CHEMBL74355 | 10.0 | Ki | 0.1 | Clinical |
| CHEMBL6607 | 10.0 | Ki | 0.1 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 106 | 384 | 7.2 |
| assay format | 89 | 651 | 7.1 |
| tissue-based format | 77 | 584 | 7.3 |
| cell membrane format | 43 | 241 | 7.0 |
| cell-based format | 26 | 194 | 7.5 |
| organism-based format | 3 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 23 | 33 | 6.4 |
| tissue-based format | 21 | 86 | 7.8 |
| cell-based format | 15 | 49 | 7.0 |
| organism-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 1 | 7.2 |
| tissue-based format | 1 | 1 | 5.7 |