Skip to main content
Evidence Snapshot

5-hydroxytryptamine receptor 2A

CHEMBL322 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T06:17:30Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL322
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 5-hydroxytryptamine receptor 2A as ChEMBL target CHEMBL322, mapped to UniProt P14842. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
5-hydroxytryptamine receptor 2A
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL322
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P14842
5-hydroxytryptamine receptor 2A
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why 5-hydroxytryptamine receptor 2A matters

As of 2026-09-13

5-hydroxytryptamine receptor 2A is reviewed as 5-hydroxytryptamine receptor 2A (UniProt P14842); the current evidence base includes 29 approved drugs, 2527 compounds, and 407 assays, with lead potency reaching pChEMBL 10.9.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 29 approved drugs, 2527 compounds, and 407 assays for this target. The dominant activity type is KI. CHEMBL3763812 is the current potency anchor at pChEMBL 10.9.

Use CHEMBL3763812 as the tractability anchor when discussing potency (pChEMBL 10.9).

Activity source · ChEMBL 36 via Core Engine
29 approved pChEMBL 10.9
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why 5-hydroxytryptamine receptor 2A matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P14842, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2527
Total Compounds
407
Total Assays
29
Approved Drugs
IC50: 541.0, KI: 2258.0, EC50: 135.0, KD: 90.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL3763812
 10.9 Ki —
No preferred name
CHEMBL1927096
 10.8 Ki —
No preferred name
CHEMBL1927096
 10.7 IC50 —
No preferred name
CHEMBL4205290
 10.7 Ki —
No preferred name
CHEMBL3763474
 10.4 Ki —

Approved Drugs

Structure Compound First Approval
BREXPIPRAZOLE
CHEMBL2105760
 2015
LURASIDONE
CHEMBL1237021
 2010
ARIPIPRAZOLE
CHEMBL1112
 2002
ZIPRASIDONE
CHEMBL708
 2001
QUETIAPINE
CHEMBL716
 1997
SERTINDOLE
CHEMBL12713
 1996
OLANZAPINE
CHEMBL715
 1996
MIRTAZAPINE
CHEMBL654
 1996
NEFAZODONE
CHEMBL623
 1994
RISPERIDONE
CHEMBL85
 1993
CLOZAPINE
CHEMBL42
 1989
BUSPIRONE
CHEMBL49
 1986
TRAZODONE
CHEMBL621
 1981
LOXAPINE
CHEMBL831
 1975
HALOPERIDOL
CHEMBL54
 1967
METHYSERGIDE
CHEMBL1065
 1962
CYPROHEPTADINE
CHEMBL516
 1961
MIANSERIN
CHEMBL6437
 —
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T06:17:30Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL322