Assay Detail
Binding
CHEMBL697304
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Inhibition of human tie-2 kinase.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pyrazolo[3,4-d]pyrimidines containing an extended 3-substituent as potent inhibitors of Lck -- a selectivity insight.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.95 | 6.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402673 | — | — | 1 | 6.86 |
| CHEMBL47787 | — | — | 1 | 6.28 |
| CHEMBL46785 | — | — | 1 | 6.22 |
| CHEMBL46176 | — | — | 1 | 6.05 |
| CHEMBL295528 | — | — | 1 | 6.04 |
| CHEMBL45651 | — | — | 1 | 6.03 |
| CHEMBL417006 | — | — | 1 | 5.84 |
| CHEMBL295601 | — | — | 1 | 5.61 |
| CHEMBL297363 | — | — | 1 | 5.33 |
| CHEMBL45693 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402673 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL47787 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL46785 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL46176 | — | IC50 | = | 888.0 | nM | 6.05 |
| CHEMBL295528 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL45651 | — | IC50 | = | 933.0 | nM | 6.03 |
| CHEMBL417006 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL295601 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL297363 | — | IC50 | = | 4680.0 | nM | 5.33 |
| CHEMBL45693 | — | IC50 | = | 5730.0 | nM | 5.24 |