Assay Detail
Binding
CHEMBL697360
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In vitro binding affinity against Ionotropic glutamate receptor AMPA binding site using [3H]- AMPA as radioligand on rat cortical synaptosomal membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: amino acid derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.28 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293206 | — | — | 1 | 7.20 |
| CHEMBL431382 | — | — | 1 | 6.85 |
| CHEMBL73704 | — | — | 1 | 5.93 |
| CHEMBL75761 | — | — | 1 | 5.80 |
| CHEMBL307667 | — | — | 1 | 5.63 |
| CHEMBL419638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293206 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL431382 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL73704 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL75761 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL307667 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL419638 | — | IC50 | > | 10000.0 | nM | - |