Compound Detail
CHEMBL307667
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Basic Information
| ChEMBL ID | CHEMBL307667 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BNRHOJBZJFRBFW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
370.2
MW (Da)
1.88
ALogP
6
HBA
3
HBD
106.8
PSA (Ų)
0.74
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.63 | 5.63 | 2320.0 | 1 |
| Glutamate receptor ionotropic AMPA CHEMBL2096670 | IC50 | 5.63 | 5.63 | 2320.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 2320.0 | nM | 5.63 | In vitro binding affinity against Ionotropic glutamate receptor AMPA binding sit... | 10377233 |
| Glutamate receptor ionotropic AMPA | IC50 | = | 2320.0 | nM | 5.63 | Displacement of [3H]AMPA from AMPA receptor (unknown origin) | 34998058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10377233 | 10.1021/jm980455n | Glutamate receptor ionotropic, AMPA | 1 |
| 10377233 | 10.1021/jm980455n | No relevant target | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | Glutamate receptor ionotropic AMPA | 1 |
| 34998058 | 10.1016/j.ejmech.2021.114085 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine