Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL697366

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 5'-(N-ethylcarbamoyl)adenosine-elicited stimulation of adenylate cyclase in human platelet membranes
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Adenosine A2 receptor (CHEMBL2094257)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

8-Aryl-and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors.
Shamim MT, Ukena D, Padgett WL, Hong O, Daly JW.
J Med Chem (1988) 31 : 613 -617
PubMed 3346878 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 6.11 7.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL27155 1 7.32
CHEMBL156627 1 7.27
CHEMBL347866 1 7.11
CHEMBL157856 1 6.85
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] 1 6.85
CHEMBL350469 1 6.75
CHEMBL160369 1 6.72
CHEMBL345595 1 6.62
CHEMBL423239 1 6.50
CHEMBL156863 1 6.09
CHEMBL158077 1 5.92
CHEMBL157833 1 5.72
CHEMBL156178 1 5.70
CHEMBL158507 1 5.68
CHEMBL346126 1 5.62
CHEMBL160704 1 5.57
CHEMBL347687 1 5.54
CHEMBL157836 1 5.44
CHEMBL156055 1 5.42
CHEMBL155951 1 5.36
CHEMBL155791 1 5.16
CHEMBL157655 1 5.13

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL27155 Ki = 48.0 nM 7.32
CHEMBL156627 Ki = 54.0 nM 7.27
CHEMBL347866 Ki = 77.0 nM 7.11
CHEMBL157856 Ki = 140.0 nM 6.85
CHEMBL183 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] Ki = 140.0 nM 6.85
CHEMBL350469 Ki = 180.0 nM 6.75
CHEMBL160369 Ki = 190.0 nM 6.72
CHEMBL345595 Ki = 240.0 nM 6.62
CHEMBL423239 Ki = 320.0 nM 6.50
CHEMBL156863 Ki = 820.0 nM 6.09
CHEMBL158077 Ki = 1200.0 nM 5.92
CHEMBL157833 Ki = 1900.0 nM 5.72
CHEMBL156178 Ki = 2000.0 nM 5.70
CHEMBL158507 Ki = 2100.0 nM 5.68
CHEMBL346126 Ki = 2400.0 nM 5.62
CHEMBL160704 Ki = 2700.0 nM 5.57
CHEMBL347687 Ki = 2900.0 nM 5.54
CHEMBL157836 Ki = 3600.0 nM 5.44
CHEMBL156055 Ki = 3800.0 nM 5.42
CHEMBL155951 Ki = 4400.0 nM 5.36
CHEMBL155791 Ki = 6900.0 nM 5.16
CHEMBL157655 Ki = 7400.0 nM 5.13