Assay Detail
Functional
CHEMBL697368
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Inhibitory activity against U-46,619-induced (1 uM) human platelet activation (aggregation)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of trimetoquinol derivatives: novel thromboxane A2/prostaglandin H2 antagonists with diminished beta-adrenergic agonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.15 | 5.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | 2.0 | 1 | 5.94 |
| CHEMBL170451 | — | — | 1 | 5.90 |
| CHEMBL172163 | — | — | 1 | 4.42 |
| CHEMBL367394 | — | — | 1 | 4.35 |
| CHEMBL172042 | — | — | 1 | - |
| CHEMBL173039 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL174984 | TRETOQUINOL | IC50 | = | 1148.15 | nM | 5.94 |
| CHEMBL170451 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL172163 | — | IC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL367394 | — | IC50 | = | 44668.36 | nM | 4.35 |
| CHEMBL172042 | — | IC50 | = | 199526.23 | nM | - |
| CHEMBL173039 | — | IC50 | = | 128824.96 | nM | - |