Assay Detail
Functional
CHEMBL697369
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration for displacing [3H]iloprost from human platelet membrane at 5.4 nM at 37 degree C
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonprostanoid prostacyclin mimetics. 5. Structure-activity relationships associated with [3-[4-(4,5-diphenyl-2-oxazolyl)-5- oxazolyl]phenoxy]acetic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.04 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125569 | — | — | 1 | 8.27 |
| CHEMBL326075 | — | — | 1 | 8.22 |
| CHEMBL127432 | — | — | 1 | 7.44 |
| CHEMBL494 | ILOPROST | 4.0 | 1 | 7.32 |
| CHEMBL117835 | — | — | 1 | 6.61 |
| CHEMBL340197 | — | — | 1 | 6.52 |
| CHEMBL338107 | — | — | 1 | 6.47 |
| CHEMBL127616 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125569 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL326075 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL127432 | — | IC50 | = | 36.6 | nM | 7.44 |
| CHEMBL494 | ILOPROST | IC50 | = | 47.7 | nM | 7.32 |
| CHEMBL117835 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL340197 | — | IC50 | = | 302.0 | nM | 6.52 |
| CHEMBL338107 | — | IC50 | = | 337.0 | nM | 6.47 |
| CHEMBL127616 | — | IC50 | = | 3200.0 | nM | 5.50 |