Assay Detail
Functional
CHEMBL697422
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against GluR5 expressed in HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, kainate 1 (CHEMBL1918) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.00 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301536 | — | — | 1 | 5.60 |
| CHEMBL59284 | — | — | 1 | 5.48 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 4.79 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301536 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL59284 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL275040 | KAINIC ACID | EC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 75000.0 | nM | 4.12 |