Assay Detail
Binding
CHEMBL697495
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Inhibitory activity against histone deacetylase (HDAC)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Amide analogues of TSA: synthesis, binding mode analysis and HDAC inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.53 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.92 |
| CHEMBL46942 | — | — | 1 | 6.82 |
| CHEMBL55974 | — | — | 1 | 6.45 |
| CHEMBL417594 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL46942 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL55974 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL417594 | — | IC50 | = | 12187.0 | nM | 4.91 |