Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL697496

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against rat liver Histone deacetylase
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2095943)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Histone deacetylase inhibitors.
Miller TA, Witter DJ, Belvedere S.
J Med Chem (2003) 46 : 5097 -5116
PubMed 14613312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 6.54 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 2 7.92
CHEMBL435643 1 7.42
CHEMBL140000 1 7.34
CHEMBL331150 1 6.89
CHEMBL143047 1 6.84
CHEMBL98 VORINOSTAT 4.0 1 6.78
CHEMBL46942 1 6.61
CHEMBL320038 1 6.58
CHEMBL143327 1 6.58
CHEMBL95959 1 6.57
CHEMBL111993 1 6.51
CHEMBL264629 1 6.50
CHEMBL149606 1 6.45
CHEMBL143734 1 6.43
CHEMBL111919 1 6.41
CHEMBL113095 1 6.34
CHEMBL113337 1 6.29
CHEMBL146202 1 6.29
CHEMBL110906 1 6.10
CHEMBL46941 1 6.10
CHEMBL326022 1 6.08
CHEMBL109960 1 6.06
CHEMBL419029 1 6.00
CHEMBL139999 1 5.80
CHEMBL146867 1 5.68
CHEMBL142305 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 12.0 nM 7.92
CHEMBL99 TRICHOSTATIN IC50 = 26.0 nM 7.58
CHEMBL435643 IC50 = 38.0 nM 7.42
CHEMBL140000 IC50 = 46.0 nM 7.34
CHEMBL331150 IC50 = 130.0 nM 6.89
CHEMBL143047 IC50 = 145.0 nM 6.84
CHEMBL98 VORINOSTAT IC50 = 165.0 nM 6.78
CHEMBL46942 IC50 = 244.0 nM 6.61
CHEMBL320038 IC50 = 260.0 nM 6.58
CHEMBL143327 IC50 = 265.0 nM 6.58
CHEMBL95959 IC50 = 270.0 nM 6.57
CHEMBL111993 IC50 = 310.0 nM 6.51
CHEMBL264629 IC50 = 320.0 nM 6.50
CHEMBL149606 IC50 = 357.0 nM 6.45
CHEMBL143734 IC50 = 369.0 nM 6.43
CHEMBL111919 IC50 = 390.0 nM 6.41
CHEMBL113095 IC50 = 460.0 nM 6.34
CHEMBL113337 IC50 = 510.0 nM 6.29
CHEMBL146202 IC50 = 515.0 nM 6.29
CHEMBL110906 IC50 = 790.0 nM 6.10
CHEMBL46941 IC50 = 800.0 nM 6.10
CHEMBL326022 IC50 = 840.0 nM 6.08
CHEMBL109960 IC50 = 880.0 nM 6.06
CHEMBL419029 IC50 = 1010.0 nM 6.00
CHEMBL139999 IC50 = 1566.0 nM 5.80
CHEMBL146867 IC50 = 2100.0 nM 5.68
CHEMBL142305 IC50 > 10000.0 nM -