Assay Detail
Binding
CHEMBL697534
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Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of a pharmacophore model for histamine H3 receptor antagonists, using the newly developed molecular modeling program SLATE.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.82 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43934 | — | — | 1 | 9.30 |
| CHEMBL45028 | — | — | 1 | 8.50 |
| CHEMBL46458 | — | — | 1 | 8.10 |
| CHEMBL44842 | — | — | 1 | 7.90 |
| CHEMBL47036 | — | — | 1 | 5.30 |
| CHEMBL46488 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43934 | — | Ki | = | 0.5012 | nM | 9.30 |
| CHEMBL45028 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL46458 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL44842 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL47036 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL46488 | — | Ki | < | 100000.0 | nM | - |