Assay Detail
Binding
CHEMBL697538
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Binding affinity at rat cortical Histamine H3 receptor
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aminoalkoxybiphenylnitriles as histamine-3 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 7.20 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL105762 | — | — | 1 | 8.19 |
| CHEMBL323562 | — | — | 1 | 8.01 |
| CHEMBL319000 | — | — | 1 | 7.87 |
| CHEMBL105967 | — | — | 1 | 7.87 |
| CHEMBL2112461 | — | — | 1 | 7.81 |
| CHEMBL105515 | — | — | 1 | 7.79 |
| CHEMBL102984 | — | — | 1 | 7.64 |
| CHEMBL106483 | — | — | 1 | 7.60 |
| CHEMBL322873 | — | — | 1 | 7.58 |
| CHEMBL320178 | — | — | 1 | 7.55 |
| CHEMBL106545 | — | — | 1 | 7.53 |
| CHEMBL102416 | — | — | 1 | 7.50 |
| CHEMBL101692 | — | — | 1 | 7.25 |
| CHEMBL421026 | — | — | 1 | 7.18 |
| CHEMBL106596 | — | — | 1 | 7.09 |
| CHEMBL105669 | — | — | 1 | 6.99 |
| CHEMBL317900 | — | — | 1 | 6.95 |
| CHEMBL105567 | — | — | 1 | 6.68 |
| CHEMBL106602 | — | — | 1 | 6.64 |
| CHEMBL446885 | — | — | 1 | 6.62 |
| CHEMBL105483 | — | — | 1 | 6.59 |
| CHEMBL105594 | — | — | 1 | 6.23 |
| CHEMBL104947 | — | — | 1 | 6.06 |
| CHEMBL419912 | — | — | 1 | 5.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL105762 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL323562 | — | Ki | = | 9.772 | nM | 8.01 |
| CHEMBL319000 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL105967 | — | Ki | = | 13.49 | nM | 7.87 |
| CHEMBL2112461 | — | Ki | = | 15.49 | nM | 7.81 |
| CHEMBL105515 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL102984 | — | Ki | = | 22.91 | nM | 7.64 |
| CHEMBL106483 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL322873 | — | Ki | = | 26.3 | nM | 7.58 |
| CHEMBL320178 | — | Ki | = | 28.18 | nM | 7.55 |
| CHEMBL106545 | — | Ki | = | 29.51 | nM | 7.53 |
| CHEMBL102416 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL101692 | — | Ki | = | 56.23 | nM | 7.25 |
| CHEMBL421026 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL106596 | — | Ki | = | 81.28 | nM | 7.09 |
| CHEMBL105669 | — | Ki | = | 102.33 | nM | 6.99 |
| CHEMBL317900 | — | Ki | = | 112.2 | nM | 6.95 |
| CHEMBL105567 | — | Ki | = | 208.93 | nM | 6.68 |
| CHEMBL106602 | — | Ki | = | 229.09 | nM | 6.64 |
| CHEMBL446885 | — | Ki | = | 239.88 | nM | 6.62 |
| CHEMBL105483 | — | Ki | = | 257.04 | nM | 6.59 |
| CHEMBL105594 | — | Ki | = | 588.84 | nM | 6.23 |
| CHEMBL104947 | — | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL419912 | — | Ki | = | 2754.23 | nM | 5.56 |