Assay Detail
Binding
CHEMBL697539
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Binding affinity of compound against Histamine H3 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.35 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278462 | CIPRALISANT | 2.0 | 1 | 9.90 |
| CHEMBL278276 | — | — | 1 | 9.40 |
| CHEMBL13559 | VUF-5296 | — | 1 | 8.50 |
| CHEMBL18554 | — | — | 1 | 7.70 |
| CHEMBL13795 | VUF-5297 | — | 1 | 7.60 |
| CHEMBL19469 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278462 | CIPRALISANT | Ki | = | 0.1259 | nM | 9.90 |
| CHEMBL278276 | — | Ki | = | 0.3981 | nM | 9.40 |
| CHEMBL13559 | VUF-5296 | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL18554 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL13795 | VUF-5297 | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL19469 | — | Ki | = | 100.0 | nM | 7.00 |