Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL697541

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards rat cortical H3 receptor
ChEMBL ↗
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Histamine H3 receptor (CHEMBL4124) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: novel and selective histamine H3 receptor antagonists.
Faghih R, Dwight W, Pan JB, Fox GB, Krueger KM, Esbenshade TA, McVey JM, Marsh K, Bennani YL, Hancock AA.
Bioorg Med Chem Lett (2003) 13 : 1325 -1328
PubMed 12657274 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 48 7.73 9.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL278462 CIPRALISANT 2.0 1 9.71
CHEMBL280590 — — 1 8.99
CHEMBL27979 A-349,821 — 1 8.78
CHEMBL283313 — — 1 8.69
CHEMBL433031 — — 1 8.55
CHEMBL25519 — — 1 8.55
CHEMBL24863 — — 1 8.53
CHEMBL25205 — — 1 8.44
CHEMBL25342 — — 1 8.42
CHEMBL27933 — — 1 8.38
CHEMBL27501 — — 1 8.29
CHEMBL26880 — — 1 8.18
CHEMBL279463 — — 1 8.14
CHEMBL25685 — — 1 8.08
CHEMBL27209 — — 1 8.06
CHEMBL27697 — — 1 8.05
CHEMBL281640 — — 1 8.04
CHEMBL27444 — — 1 7.99
CHEMBL27665 — — 1 7.89
CHEMBL282903 — — 1 7.86
CHEMBL24468 — — 1 7.79
CHEMBL436340 — — 1 7.76
CHEMBL2113223 — — 1 7.73
CHEMBL27115 — — 1 7.68
CHEMBL27835 — — 1 7.67
CHEMBL25501 — — 1 7.59
CHEMBL2113222 — — 1 7.56
CHEMBL280895 — — 1 7.55
CHEMBL282685 — — 1 7.54
CHEMBL2113224 — — 1 7.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL278462 CIPRALISANT Ki = 0.195 nM 9.71
CHEMBL280590 — Ki = 1.023 nM 8.99
CHEMBL27979 A-349,821 Ki = 1.66 nM 8.78
CHEMBL283313 — Ki = 2.042 nM 8.69
CHEMBL433031 — Ki = 2.818 nM 8.55
CHEMBL25519 — Ki = 2.818 nM 8.55
CHEMBL24863 — Ki = 2.951 nM 8.53
CHEMBL25205 — Ki = 3.631 nM 8.44
CHEMBL25342 — Ki = 3.802 nM 8.42
CHEMBL27933 — Ki = 4.169 nM 8.38
CHEMBL27501 — Ki = 5.129 nM 8.29
CHEMBL26880 — Ki = 6.607 nM 8.18
CHEMBL279463 — Ki = 7.244 nM 8.14
CHEMBL25685 — Ki = 8.318 nM 8.08
CHEMBL27209 — Ki = 8.71 nM 8.06
CHEMBL27697 — Ki = 8.913 nM 8.05
CHEMBL281640 — Ki = 9.12 nM 8.04
CHEMBL27444 — Ki = 10.23 nM 7.99
CHEMBL27665 — Ki = 12.88 nM 7.89
CHEMBL282903 — Ki = 13.8 nM 7.86
CHEMBL24468 — Ki = 16.22 nM 7.79
CHEMBL436340 — Ki = 17.38 nM 7.76
CHEMBL2113223 — Ki = 18.62 nM 7.73
CHEMBL27115 — Ki = 20.89 nM 7.68
CHEMBL27835 — Ki = 21.38 nM 7.67
CHEMBL25501 — Ki = 25.7 nM 7.59
CHEMBL2113222 — Ki = 27.54 nM 7.56
CHEMBL280895 — Ki = 28.18 nM 7.55
CHEMBL282685 — Ki = 28.84 nM 7.54
CHEMBL2113224 — Ki = 29.51 nM 7.53
CHEMBL24865 — Ki = 30.9 nM 7.51
CHEMBL24198 — Ki = 32.36 nM 7.49
CHEMBL27339 — Ki = 33.11 nM 7.48
CHEMBL25688 — Ki = 41.69 nM 7.38
CHEMBL282062 — Ki = 42.66 nM 7.37
CHEMBL24921 — Ki = 42.66 nM 7.37
CHEMBL24847 — Ki = 52.48 nM 7.28
CHEMBL282016 — Ki = 57.54 nM 7.24
CHEMBL27545 — Ki = 70.79 nM 7.15
CHEMBL24352 — Ki = 97.72 nM 7.01
CHEMBL28271 — Ki = 112.2 nM 6.95
CHEMBL25126 — Ki = 114.82 nM 6.94
CHEMBL24126 — Ki = 128.82 nM 6.89
CHEMBL27343 — Ki = 134.9 nM 6.87
CHEMBL281287 — Ki = 177.83 nM 6.75
CHEMBL25290 — Ki = 218.78 nM 6.66
CHEMBL284320 — Ki = 407.38 nM 6.39
CHEMBL283451 — Ki = 478.63 nM 6.32