Assay Detail
Functional
CHEMBL697583
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Tested in vitro against HCMV AD-169 strain in MRC-5 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Cell Type | MRC5 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.27 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223737 | GS-438 | -1.0 | 1 | 7.05 |
| CHEMBL92289 | — | — | 1 | 6.10 |
| CHEMBL419692 | — | — | 1 | 5.80 |
| CHEMBL432032 | — | — | 1 | 4.82 |
| CHEMBL91794 | — | — | 1 | 4.80 |
| CHEMBL92761 | — | — | 1 | 4.80 |
| CHEMBL93425 | — | — | 1 | 4.48 |
| CHEMBL93384 | — | — | 1 | 4.29 |
| CHEMBL329554 | — | — | 1 | - |
| CHEMBL90801 | — | — | 1 | - |
| CHEMBL314742 | — | — | 1 | - |
| CHEMBL93006 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223737 | GS-438 | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL92289 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL419692 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL432032 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL91794 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL92761 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL93425 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL93384 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL329554 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL90801 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL314742 | — | IC50 | = | 162000.0 | nM | - |
| CHEMBL93006 | — | IC50 | = | 150000.0 | nM | - |