Assay Detail
Functional
CHEMBL697600
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Inhibition of LPS-induced p38-related TNF alpha release from human monocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Pyrroles and other heterocycles as inhibitors of p38 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.30 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316275 | — | — | 1 | 7.64 |
| CHEMBL88486 | — | — | 1 | 7.19 |
| CHEMBL10 | SB-203580 | — | 1 | 7.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316275 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL88486 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL10 | SB-203580 | IC50 | = | 83.0 | nM | 7.08 |