Assay Detail
Functional
CHEMBL697606
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Ability to block the release of TNF-alpha in human monocytes
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.84 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166320 | — | — | 1 | 8.05 |
| CHEMBL162663 | — | — | 1 | 7.62 |
| CHEMBL165158 | — | — | 1 | 7.58 |
| CHEMBL352153 | — | — | 1 | 7.43 |
| CHEMBL349274 | — | — | 1 | 7.10 |
| CHEMBL351065 | — | — | 1 | 7.09 |
| CHEMBL353349 | — | — | 1 | 6.92 |
| CHEMBL282934 | — | — | 1 | 6.85 |
| CHEMBL350339 | — | — | 1 | 6.75 |
| CHEMBL161991 | — | — | 1 | 6.72 |
| CHEMBL166306 | — | — | 1 | 6.58 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 6.54 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.51 |
| CHEMBL280185 | — | — | 1 | 6.50 |
| CHEMBL164067 | — | — | 1 | 6.44 |
| CHEMBL422031 | — | — | 1 | 5.93 |
| CHEMBL350368 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166320 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL162663 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL165158 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL352153 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL349274 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL351065 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL353349 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL282934 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL350339 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL161991 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL166306 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL280185 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL164067 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL422031 | — | IC50 | = | 1170.0 | nM | 5.93 |
| CHEMBL350368 | — | IC50 | = | 2310.0 | nM | 5.64 |