Assay Detail
Binding
CHEMBL697661
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Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.20 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16404 | — | — | 1 | 7.40 |
| CHEMBL15813 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16404 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL15813 | — | Ki | = | 100.0 | nM | 7.00 |