Assay Detail
Functional
CHEMBL697662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonistic activity against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Cerebral cortex |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel carbamates as potent histamine H3 receptor antagonists with high in vitro and oral in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.18 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16404 | — | — | 1 | 7.38 |
| CHEMBL15813 | — | — | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16404 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL15813 | — | Ki | = | 105.0 | nM | 6.98 |