Assay Detail
Binding
CHEMBL697800
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the inhibition of binding of [3H]AMPA radioligand to Ionotropic glutamate receptor AMPA to cortical membranes from rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Isatin oximes - A novel series of bioavailable non-NMDA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.90 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 7.00 |
| CHEMBL9790 | — | — | 1 | 6.48 |
| CHEMBL10103 | — | — | 1 | 5.75 |
| CHEMBL9804 | — | — | 1 | 5.55 |
| CHEMBL10182 | — | — | 1 | 5.55 |
| CHEMBL9750 | — | — | 1 | 5.09 |
| CHEMBL607705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL9790 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL10103 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL9804 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL10182 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL9750 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL607705 | — | IC50 | > | 30000.0 | nM | - |