Compound Detail
CHEMBL10103
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Basic Information
| ChEMBL ID | CHEMBL10103 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WJFLIEWDZIJXPZ-UHFFFAOYSA-N |
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
323.4
MW (Da)
2.40
ALogP
5
HBA
2
HBD
102.8
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 6.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.82 | 5.455 | 150.0 | 2 |
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 5.75 | 5.75 | 1800.0 | 2 |
| Rattus norvegicus CHEMBL376 | IC50 | 5.46 | 5.46 | 3500.0 | 1 |
| Mus musculus CHEMBL375 | IC50 | 5.27 | 5.27 | 5400.0 | 1 |
| Glutamate receptor ionotropic, kainate CHEMBL2094119 | IC50 | 4.57 | 4.57 | 27000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 150.0 | nM | 6.82 | Displacement of [3H]AMPA from AMPA receptor in rat cortical membrane in presence... | 20356304 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 1800.0 | nM | 5.75 | Binding affinity towards AMPA receptor using [3H]AMPA as radioligand | - |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 1800.0 | nM | 5.75 | Tested for the inhibition of binding of [3H]AMPA radioligand to Ionotropic gluta... | - |
| Rattus norvegicus | IC50 | = | 3500.0 | nM | 5.46 | Tested for the ability to inhibit AMPA (5 uM) induced depolarizations in rat cor... | - |
| Mus musculus | IC50 | = | 5400.0 | nM | 5.27 | Tested for the [Ca2+] i induced elevation using cultured mouse cortical neurons,... | - |
| Glutamate receptor ionotropic, kainate | IC50 | = | 27000.0 | nM | 4.57 | Tested for the inhibition of binding of [3H]kainate radioligand to Ionotropic gl... | - |
| Unchecked | IC50 | = | 81000.0 | nM | 4.09 | Displacement of [3H]kainate from kainate receptor in rat cortical membrane | 20356304 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80101-8 | Mus musculus | 3 |
| - | 10.1016/S0960-894X(00)80101-8 | Rattus norvegicus | 2 |
| 20356304 | 10.1021/jm901688m | Unchecked | 2 |
| - | 10.1016/S0960-894X(01)80147-5 | Glutamate receptor ionotropic, AMPA | 1 |
| - | 10.1016/S0960-894X(00)80101-8 | Glutamate receptor ionotropic, AMPA | 1 |
| - | 10.1016/S0960-894X(00)80101-8 | Glutamate receptor ionotropic, kainate | 1 |
| 20356304 | 10.1021/jm901688m | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine