Assay Detail
Functional
CHEMBL785232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for the ability to inhibit AMPA (5 uM) induced depolarizations in rat cortical wedge preparation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Isatin oximes - A novel series of bioavailable non-NMDA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.72 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 6.52 |
| CHEMBL9804 | — | — | 1 | 5.60 |
| CHEMBL10103 | — | — | 1 | 5.46 |
| CHEMBL10182 | — | — | 1 | 5.28 |
| CHEMBL9750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL9804 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL10103 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL10182 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL9750 | — | IC50 | > | 30000.0 | nM | - |