Assay Detail
Functional
CHEMBL735761
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Tested for the [Ca2+] i induced elevation using cultured mouse cortical neurons, exposed to 5 uM AMPA for 4 minutes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Isatin oximes - A novel series of bioavailable non-NMDA antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.55 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222519 | NBQX | — | 1 | 6.52 |
| CHEMBL9804 | — | — | 1 | 5.46 |
| CHEMBL10103 | — | — | 1 | 5.27 |
| CHEMBL10182 | — | — | 1 | 4.96 |
| CHEMBL9750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222519 | NBQX | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL9804 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL10103 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL10182 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL9750 | — | IC50 | > | 30000.0 | nM | - |