Assay Detail
Binding
CHEMBL697884
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Binding affinity at Ionotropic glutamate receptor AMPA in rat cortical tissue by [3H]AMPA displacement.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.79 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308699 | — | — | 1 | 5.52 |
| CHEMBL440869 | — | — | 1 | 5.38 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 5.32 |
| CHEMBL71764 | — | — | 1 | 5.01 |
| CHEMBL308941 | — | — | 1 | 4.89 |
| CHEMBL71581 | — | — | 1 | 4.78 |
| CHEMBL308563 | — | — | 1 | 4.64 |
| CHEMBL446405 | — | — | 1 | 4.62 |
| CHEMBL69614 | — | — | 1 | 4.24 |
| CHEMBL71755 | — | — | 1 | 4.22 |
| CHEMBL72123 | — | — | 1 | 4.07 |
| CHEMBL71163 | — | — | 1 | - |
| CHEMBL309097 | — | — | 1 | - |
| CHEMBL406333 | — | — | 1 | - |
| CHEMBL303600 | — | — | 1 | - |
| CHEMBL303197 | — | — | 1 | - |
| CHEMBL72655 | — | — | 1 | - |
| CHEMBL305456 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308699 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL440869 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL71764 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL308941 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL71581 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL308563 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL446405 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL69614 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL71755 | — | IC50 | = | 59600.0 | nM | 4.22 |
| CHEMBL72123 | — | IC50 | = | 84500.0 | nM | 4.07 |
| CHEMBL71163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL309097 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL406333 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303600 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303197 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72655 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL305456 | — | IC50 | > | 100000.0 | nM | - |