Compound Detail
CHEMBL69614
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Basic Information
| ChEMBL ID | CHEMBL69614 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RAOLIHHDXLVRHB-RVMXOQNASA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
307.4
MW (Da)
1.39
ALogP
5
HBA
3
HBD
103.8
PSA (Ų)
0.69
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.56
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 4.56 | 4.4 | 27600.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 27600.0 | nM | 4.56 | AMPA receptor antagonistic activity as inhibition of depolarizations induced by ... | 8667365 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 57000.0 | nM | 4.24 | Binding affinity at Ionotropic glutamate receptor AMPA in rat cortical tissue by... | 8667365 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8667365 | 10.1021/jm950912p | Glutamate NMDA receptor | 2 |
| 8667365 | 10.1021/jm950912p | Glutamate receptor ionotropic, AMPA | 2 |
| 8667365 | 10.1021/jm950912p | Glutamate receptor ionotropic, kainate | 2 |
Data from ChEMBL 36 via Core Engine