Assay Detail
Functional
CHEMBL884120
Review assay metadata, readout intent, target linkage, and publication context from the same page.
AMPA receptor antagonistic activity as inhibition of depolarizations induced by 40 uM AMPA in rat cortical slice preparation
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.57 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | 2.0 | 1 | 5.22 |
| CHEMBL69614 | — | — | 1 | 4.56 |
| CHEMBL446405 | — | — | 1 | 4.53 |
| CHEMBL308941 | — | — | 1 | 4.39 |
| CHEMBL303197 | — | — | 1 | 4.16 |
| CHEMBL305456 | — | — | 1 | - |
| CHEMBL71163 | — | — | 1 | - |
| CHEMBL309097 | — | — | 1 | - |
| CHEMBL406333 | — | — | 1 | - |
| CHEMBL303600 | — | — | 1 | - |
| CHEMBL72655 | — | — | 1 | - |
| CHEMBL71755 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14935 | TEZAMPANEL ANHYDROUS | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL69614 | — | IC50 | = | 27600.0 | nM | 4.56 |
| CHEMBL446405 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL308941 | — | IC50 | = | 40900.0 | nM | 4.39 |
| CHEMBL303197 | — | IC50 | = | 69300.0 | nM | 4.16 |
| CHEMBL305456 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL71163 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL309097 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL406333 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL303600 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL72655 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL71755 | — | IC50 | > | 100000.0 | nM | - |