Assay Detail
Binding
CHEMBL697887
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Binding affinity was measured by [3H]- Ionotropic glutamate receptor AMPA binding assay.
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Heterocyclic excitatory amino acids. Synthesis and biological activity of novel analogues of AMPA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.00 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12442 | — | — | 1 | 7.70 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12442 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL575060 | GLUTAMIC ACID | IC50 | = | 500.0 | nM | 6.30 |