Assay Detail
Binding
CHEMBL697888
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Binding affinity for AMPA receptor using [3H]AMPA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, AMPA (CHEMBL2093871) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.49 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL268762 | — | — | 1 | 6.50 |
| CHEMBL315663 | — | — | 1 | 6.32 |
| CHEMBL88184 | — | — | 1 | 6.10 |
| CHEMBL10047 | — | — | 1 | 4.96 |
| CHEMBL9698 | — | — | 1 | 4.64 |
| CHEMBL9515 | — | — | 1 | 4.41 |
| CHEMBL9777 | — | — | 1 | - |
| CHEMBL273291 | — | — | 1 | - |
| CHEMBL9752 | — | — | 1 | - |
| CHEMBL9822 | — | — | 1 | - |
| CHEMBL268472 | — | — | 1 | - |
| CHEMBL9758 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL268762 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL315663 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL88184 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL10047 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL9698 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL9515 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL9777 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL273291 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL9752 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL9822 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL268472 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL9758 | — | IC50 | > | 100000.0 | nM | - |