Compound Detail
CHEMBL88184
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Basic Information
| ChEMBL ID | CHEMBL88184 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PEHXWVXZPICGAV-BYPYZUCNSA-N |
1
Targets
10
Activities
3
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
172.1
MW (Da)
-0.67
ALogP
5
HBA
3
HBD
109.6
PSA (Ų)
0.56
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 4 meas.
Ki 4 meas.
IC50 2 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 6.1 | 6.1 | 800.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 800.0 | nM | 6.1 | Concentration which causes 50% reduction in receptor binding affinity against Io... | 11831912 |
| Glutamate receptor ionotropic, AMPA | IC50 | = | 800.0 | nM | 6.1 | Binding affinity for AMPA receptor using [3H]AMPA | 11297452 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 4 | 1 |
| 12213064 | 10.1021/jm020122x | Metabotropic glutamate receptor 4 | 1 |
| 11297452 | 10.1021/jm000441t | Metabotropic glutamate receptor 4 | 1 |
| 11297452 | 10.1021/jm000441t | Metabotropic glutamate receptor 2 | 1 |
| 11297452 | 10.1021/jm000441t | Metabotropic glutamate receptor 5 | 1 |
| 11297452 | 10.1021/jm000441t | Metabotropic glutamate receptor 1 | 1 |
| 11297452 | 10.1021/jm000441t | Rattus norvegicus | 1 |
| 11297452 | 10.1021/jm000441t | Glutamate receptor ionotropic, kainate | 1 |
| 11297452 | 10.1021/jm000441t | Glutamate NMDA receptor | 1 |
| 11297452 | 10.1021/jm000441t | Glutamate receptor ionotropic, AMPA | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 5 | 1 |
| 11831912 | 10.1021/jm010443t | Glutamate NMDA receptor | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 2 | 1 |
| 10893301 | 10.1021/jm000007r | Metabotropic glutamate receptor 1 | 1 |
| 11831912 | 10.1021/jm010443t | Metabotropic glutamate receptor 2 | 1 |
| 11831912 | 10.1021/jm010443t | Metabotropic glutamate receptor 4 | 1 |
| 11831912 | 10.1021/jm010443t | Metabotropic glutamate receptor 5 | 1 |
| 11831912 | 10.1021/jm010443t | Metabotropic glutamate receptor 1 | 1 |
| 11831912 | 10.1021/jm010443t | Rattus norvegicus | 1 |
| 11831912 | 10.1021/jm010443t | Glutamate receptor ionotropic, kainate 1 | 1 |
Data from ChEMBL 36 via Core Engine