Assay Detail
Functional
CHEMBL697913
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Inhibition of ADP-induced platelet aggregation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of cyclic AMP phosphodiesterase. 1. Analogues of cilostamide and anagrelide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.57 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | 2.0 | 1 | 6.96 |
| CHEMBL34431 | CILOSTAMIDE | 2.0 | 1 | 5.72 |
| CHEMBL760 | ANAGRELIDE | 4.0 | 1 | 5.58 |
| CHEMBL65882 | — | — | 1 | 5.40 |
| CHEMBL67513 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL34431 | CILOSTAMIDE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL760 | ANAGRELIDE | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL65882 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL67513 | — | IC50 | = | 62000.0 | nM | 4.21 |