Assay Detail
Functional
CHEMBL697933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of platelet aggregation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Inhibitors of cyclic AMP phosphodiesterase. 4. Synthesis and evaluation of potential prodrugs of lixazinone (N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro-2- oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide, RS-82856).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.65 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | 2.0 | 1 | 7.30 |
| CHEMBL308196 | — | — | 1 | 6.82 |
| CHEMBL302724 | — | — | 1 | 6.16 |
| CHEMBL305979 | — | — | 1 | 5.92 |
| CHEMBL302079 | — | — | 1 | 5.47 |
| CHEMBL69524 | — | — | 1 | 5.38 |
| CHEMBL66995 | — | — | 1 | 5.37 |
| CHEMBL422230 | — | — | 1 | 5.27 |
| CHEMBL66845 | — | — | 1 | 4.77 |
| CHEMBL67567 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69139 | LIXAZINONE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL308196 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL302724 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL305979 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL302079 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL69524 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL66995 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL422230 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL66845 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL67567 | — | IC50 | = | 100000.0 | nM | 4.00 |