Assay Detail
Functional
CHEMBL697935
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In vitro inhibitory activity was evaluated against human squalence epoxidase
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.65 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL347699 | — | — | 1 | 8.27 |
| CHEMBL27885 | — | — | 1 | 8.14 |
| CHEMBL537176 | — | — | 1 | 8.01 |
| CHEMBL346067 | — | — | 1 | 7.96 |
| CHEMBL159182 | — | — | 1 | 7.64 |
| CHEMBL157340 | — | — | 1 | 7.60 |
| CHEMBL348382 | — | — | 1 | 7.51 |
| CHEMBL160746 | — | — | 1 | 6.92 |
| CHEMBL155969 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL347699 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL27885 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL537176 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL346067 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL159182 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL157340 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL348382 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL160746 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL155969 | — | IC50 | = | 160.0 | nM | 6.80 |