Assay Detail
Functional
CHEMBL697960
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Functional Histamine H3 receptor antagonistic activity in vitro assay on synaptosomes of rat cerebral cortex
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
4-(omega-(alkyloxy)alkyl)-1H-imidazole derivatives as histamine H(3) receptor antagonists/agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.24 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88306 | — | — | 1 | 8.20 |
| CHEMBL313803 | — | — | 1 | 8.00 |
| CHEMBL330688 | — | — | 1 | 7.90 |
| CHEMBL329116 | — | — | 1 | 7.80 |
| CHEMBL89999 | — | — | 1 | 7.70 |
| CHEMBL88746 | — | — | 1 | 7.50 |
| CHEMBL88256 | — | — | 1 | 7.40 |
| CHEMBL92541 | — | — | 1 | 6.90 |
| CHEMBL91361 | — | — | 1 | 6.70 |
| CHEMBL88958 | — | — | 1 | 6.70 |
| CHEMBL90968 | — | — | 1 | 6.60 |
| CHEMBL92168 | — | — | 1 | 6.50 |
| CHEMBL328758 | — | — | 1 | 6.20 |
| CHEMBL88362 | — | — | 1 | - |
| CHEMBL88419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88306 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL313803 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL330688 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL329116 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL89999 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL88746 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL88256 | — | Ki | = | 39.81 | nM | 7.40 |
| CHEMBL92541 | — | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL91361 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL88958 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL90968 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL92168 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL328758 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL88362 | — | Ki | ~ | 1995262314968882.8 | nM | - |
| CHEMBL88419 | — | Ki | < | 1000.0 | nM | - |