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Assay Detail

CHEMBL698056

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration of the HOX that inhibits 50% of AChE (Acetylcholinesterase) activity
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Structure-activity relationships for reactivators of organophosphorus-inhibited acetylcholinesterase: quaternary salts of 2-[(hydroxyimino)methyl]imidazole.
Bedford CD, Harris RN, Howd RA, Miller A, Nolen HW, Kenley RA.
J Med Chem (1984) 27 : 1431 -1438
PubMed 6492073 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.75 5.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL33332 1 5.16
CHEMBL32768 1 5.16
CHEMBL33101 1 4.92
CHEMBL34000 1 4.82
CHEMBL32585 1 4.80
CHEMBL416772 1 4.70
CHEMBL284692 1 4.30
CHEMBL288316 1 4.10
CHEMBL748 PRALIDOXIME CHLORIDE 4.0 1 -
CHEMBL291233 OBIDOXIME CHLORIDE 2.0 1 -
CHEMBL33051 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL33332 IC50 = 7000.0 nM 5.16
CHEMBL32768 IC50 = 7000.0 nM 5.16
CHEMBL33101 IC50 = 12000.0 nM 4.92
CHEMBL34000 IC50 = 15000.0 nM 4.82
CHEMBL32585 IC50 = 16000.0 nM 4.80
CHEMBL416772 IC50 = 20000.0 nM 4.70
CHEMBL284692 IC50 = 50000.0 nM 4.30
CHEMBL288316 IC50 = 80000.0 nM 4.10
CHEMBL748 PRALIDOXIME CHLORIDE IC50 = 400000.0 nM -
CHEMBL291233 OBIDOXIME CHLORIDE IC50 = 400000.0 nM -
CHEMBL33051 IC50 = 400000.0 nM -