Assay Detail
Binding
CHEMBL698194
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Inhibitory activity against IKK1
23
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A novel series of potent and selective IKK2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.82 | 6.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337236 | — | — | 2 | 6.81 |
| CHEMBL132942 | — | — | 1 | 6.81 |
| CHEMBL131693 | — | — | 1 | 6.61 |
| CHEMBL133823 | — | — | 1 | 6.48 |
| CHEMBL129981 | — | — | 1 | 6.07 |
| CHEMBL424069 | — | — | 1 | 5.96 |
| CHEMBL133928 | — | — | 1 | 5.93 |
| CHEMBL133548 | — | — | 1 | 5.92 |
| CHEMBL338848 | — | — | 1 | 5.91 |
| CHEMBL411659 | — | — | 1 | 5.83 |
| CHEMBL336594 | — | — | 1 | 5.79 |
| CHEMBL335949 | — | — | 1 | 5.77 |
| CHEMBL130511 | — | — | 1 | 5.68 |
| CHEMBL130866 | — | — | 1 | 5.63 |
| CHEMBL134010 | — | — | 1 | 5.63 |
| CHEMBL334506 | — | — | 1 | 5.57 |
| CHEMBL132416 | — | — | 1 | 5.42 |
| CHEMBL133941 | — | — | 1 | 5.40 |
| CHEMBL130631 | — | — | 1 | 5.40 |
| CHEMBL133471 | — | — | 1 | 5.39 |
| CHEMBL341432 | — | — | 1 | 5.29 |
| CHEMBL334758 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337236 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL132942 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL131693 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL133823 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL129981 | — | IC50 | = | 851.0 | nM | 6.07 |
| CHEMBL424069 | — | IC50 | = | 1096.0 | nM | 5.96 |
| CHEMBL133928 | — | IC50 | = | 1175.0 | nM | 5.93 |
| CHEMBL133548 | — | IC50 | = | 1202.0 | nM | 5.92 |
| CHEMBL338848 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL411659 | — | IC50 | = | 1479.0 | nM | 5.83 |
| CHEMBL336594 | — | IC50 | = | 1622.0 | nM | 5.79 |
| CHEMBL335949 | — | IC50 | = | 1698.0 | nM | 5.77 |
| CHEMBL130511 | — | IC50 | = | 2089.0 | nM | 5.68 |
| CHEMBL130866 | — | IC50 | = | 2344.0 | nM | 5.63 |
| CHEMBL134010 | — | IC50 | = | 2344.0 | nM | 5.63 |
| CHEMBL334506 | — | IC50 | = | 2692.0 | nM | 5.57 |
| CHEMBL337236 | — | IC50 | = | 3090.0 | nM | 5.51 |
| CHEMBL132416 | — | IC50 | = | 3802.0 | nM | 5.42 |
| CHEMBL133941 | — | IC50 | = | 3981.0 | nM | 5.40 |
| CHEMBL130631 | — | IC50 | = | 3981.0 | nM | 5.40 |
| CHEMBL133471 | — | IC50 | = | 4074.0 | nM | 5.39 |
| CHEMBL341432 | — | IC50 | = | 5129.0 | nM | 5.29 |
| CHEMBL334758 | — | IC50 | = | 6918.0 | nM | 5.16 |